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引用本文格式: Ma Jun-Ren,Li Jiu-Zhi,Zhao Xin-Jun. Nogo-B induce oxLDL degradation and activation of liver cancer gene [J]. J. At. Mol. Phys., 2021, 38: 011003 (in Chinese) [马军仁,李九智,赵新军. Nogo-B诱导oxLDL降解与肝癌基因激活 [J]. 原子与分子物理学报, 2021, 38: 011003]
 
Nogo-B诱导oxLDL降解与肝癌基因激活
Nogo-B induce oxLDL degradation and activation of liver cancer gene
摘要点击 110  全文点击 16  投稿时间:2019-12-26  修订日期:2020-01-12
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DOI编号   
中文关键词   Nogo-B  oxLDL  降解  肝癌基因激活
英文关键词   Nogo-B  oxLDL  degradation  activation of liver cancer gene
基金项目   国家自然科学基金
作者单位E-mail
马军仁 伊犁师范大学  
李九智 新疆维吾尔自治区人民医院  
赵新军 伊犁师范大学 zhaoxinjunzxj@163.com 
中文摘要
    本文基于Hill 动力学与 Michaelis-Menten 方程,建立理论模型研究 Nogo-B 诱导oxLDL 降解与肝癌基因激活。理论模型考虑oxLDL* (降解的oxLDL)-Nogo-B-YAP 通路,研究发现,oxLDL 的降解,促进了大量的 LPA 产生,之后便会提高 Hippo 信号通路 YAP 活性,激活了癌基因的表达;经过约 5 小时 Nogo-B 表达上调,Nogo-B 决定着 Nogo-B 与ATG5 的复合体 NA,NA调控 oxLDL 的降解,未降解的 oxLDL 会诱导内质网定位的蛋白 Nogo-B 表达上调,激活了 oxLDL*-Nogo-B-YAP 通路,理论结果符合实验结果,并揭示非酒精性脂肪肝病诱发的肝癌的致病机理,可以为设计阻断肝炎向肝癌转变的通路治疗方案提供理论依据。
英文摘要
    Based on Hill kinetics and Michaelis-Menten function, we investigate Nogo-B induce oxLDL degradation and activation of liver cancer gene. Our model takes oxLDL* (degradating oxLDL)-Nogo-B-YAP path. We found the degradation of oxLDL promoted LPA largely, and then promoted the activation of YAP in Hippo signaling pathway, which activate expression of liver cancer gene. We also found, after about 5 hours, Nogo-B expression is up-regulated. Nogo-B determined the NA compounded by Nogo-B and ATG5. NA can regulate the degradation of oxLDL. oxLDL also can induce upregulation of Nogo-B expression, which activate oxLDL*-Nogo-B-YAP path. Our theoretical results are consistent with the experimental observations, and provide a fundamental understanding of the non- -alcoholic fatty liver disease inducing liver cancer. The results provide a theoretical basis for designing a pathway treatment regimen that blocks the transition of hepatitis to liver cancer.

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