Home  |  About this Journal  |  Authors  |  Referees  |  Editors  |  Contact us  |  中文版
Cite this article as: Wang Ying,Wang Ping,Zhang Guo-Liang,Zhu Tao,Jiang Zhong-Ying. Effects of Lipid Redistribution on Protocell Nanoparticles Uptake by Cells [J]. J. At. Mol. Phys.(原子与分子物理学报), 2020, 37: 1 (in Chinese)
Effects of Lipid Redistribution on Protocell Nanoparticles Uptake by Cells
Hits 199  Download times 71  Received:April 11, 2019  Revised:May 17, 2019
View Full Text  View/Add Comment  Download reader
DOI   
Key Words   Protocell Nanoparticles  Endocytosis  DLVO Theory  Membrane Fusion  Pinocytosis
Author NameAffiliationE-mail
Wang Ying National Laboratory of Solid State Microstructures, School of Physics, Nanjing University, Nanjing 210093, China 13813955964@163.com 
Wang Ping Key Laboratory of Micro-nano Electric Sensing Technology and Bionic Devices, College of Electronic and Information Engineering, Yili Normal University, Yining 835000, China 852561666@qq.com 
Zhang Guo-Liang Key Laboratory of Micro-nano Electric Sensing Technology and Bionic Devices, College of Electronic and Information Engineering, Yili Normal University, Yining 835000, China 15850515274@163.com 
Zhu Tao National Laboratory of Solid State Microstructures, School of Physics, Nanjing University, Nanjing 210093, China zhuttd@163.com 
Jiang Zhong-Ying Key Laboratory of Micro-nano Electric Sensing Technology and Bionic Devices, College of Electronic and Information Engineering, Yili Normal University, Yining 835000, China jiangzhying@163.com 
Abstract
    Coating of biomembrane on the nanoparticles can enhance their biocompatibility, targeting and controllability of inclusions release. However, the interaction mechanism between the protocell nanoparticles and cell membranes remains unclear. In this study, we have investigated the in vitro endocytosis of porous silicon nanoparticles coated with negative lipid membranes with different lateral fluidities. It was found that the fluid liquid-phase lipid coating produced a high endocytosis efficiency, while its endocytosis pathway was also different from that of the low fluid gel-phase lipid coating. Derjaguin–Landau–Verway–Overbeek theoretical analysis showed that lipid rearrangement can promote the fusion between biomembrane and cell membrane as well as particle endocytosis in the former case. However, a high energy barrier was observed in the membrane fusion in the latter case. So a pinocytosis uptake pathway was preferred. Our research deepens the understanding of the endocytosis of protocell nanoparticles. It also provides new insight and references for the design of complex nanoparticle-based drug carriers in the future.

You are the 47408 visitor.

Copyright @ 2007Editorial Office of Journal of Atomic and Molecular Physics
Address: Institute of Atomic and Molecular Physics, Sichuan University  Postcode: Chengdu 610065
Tel:QQ: 3094757965  Fax:  E-mail: jamp@scu.edu.cn
Beijing E-Tiller Co., Ltd.